Article
DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells.
Nucleic acids research - 1 Dec 2013
Jain Aklank, Bacolla Albino, Del Mundo Imee M, Zhao Junhua, Wang Guliang, Vasquez Karen M
Abstract excerpt
Sequences that have the capacity to adopt alternative (i.e. non-B) DNA structures in the human genome have been implicated in stimulating genomic instability. Previously, we found that a naturally occurring intra-molecular triplex (H-DNA) caused genetic instability in mammals largely in the form of DNA double-strand breaks. Thus, it is of interest to determine the mechanism(s) involved in processing H-DNA....
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