Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A triple-helix forming oligonucleotide targeting genomic DNA fails to induce mutation.

Mutagenesis - 1 Nov 2012

Reshat Reshat, Priestley Catherine C, Gooderham Nigel J

Abstract excerpt

Purine tracts in duplex DNA can bind oligonucleotide strands in a sequence specific manner to form triple-helix structures. Triple-helix forming oligonucleotides (TFOs) targeting supFG1 constructs have previously been shown to be mutagenic raising safety concerns for oligonucleotide-based pharmaceuticals. We have engineered a TFO, TFO27, to target the genomic Hypoxanthine-guanine phosphoribosyltransferase (HPRT)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to DNA Damage
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Genetic Loci

Share to Hypoxanthine Phosphoribosyltransferase

Share to Oligonucleotides

Share to Purines

Source

Identifiers

PMID: 22914677
DOI: 10.1093/mutage/ges037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A triple-helix forming oligonucleotide targeting genomic DNA fails to induce mutation.PMID 22914677Read ↗

The Lack of Mutagenic Potential of a Guanine-Rich Triplex Forming Oligonucleotide in Physiological Conditions.Semantic proximity Read ↗

Site-specific mutagenesis by triple helix-forming oligonucleotides containing a reactive nucleoside analog.Semantic proximity Read ↗

Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination.Semantic proximity Read ↗

Triplex targeted genomic crosslinks enter separable deletion and base substitution pathways.Semantic proximity Read ↗

Peptide nucleic acid-mediated recombination for targeted genomic repair and modification.Semantic proximity Read ↗

Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides.Semantic proximity Read ↗

Molecular analysis of mutations in the human HPRT gene.Semantic proximity Read ↗

Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides.Semantic proximity Read ↗

Molecular analysis of mutations in the human HPRT gene.Semantic proximity Read ↗

Oligonucleotide-directed mutagenesis and targeted gene correction: a mechanistic point of view.Semantic proximity Read ↗

Mutagenesis by an antisense oligonucleotide and its degradation product.Semantic proximity Read ↗

Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.