Article
Requirement of the propeptide for in vivo formation of active yeast carboxypeptidase Y.
The Journal of biological chemistry - 4 Mar 1994
Ramos C, Winther J R, Kielland-Brandt M C
Abstract excerpt
Deletions have been constructed in the region encoding the 91-amino acid propeptide of the vacuolar enzyme carboxypeptidase Y of Saccharomyces cerevisiae, and in vivo effects of these mutations on the intracellular transport of the mutant proenzymes have been examined. Deletions did not include the vacuolar targeting signal, and none of the mutated forms of procarboxypeptidase Y was found to be secreted. All...
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