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Article

The functional efficiency of a mammalian signal peptide is directly related to its hydrophobicity.

The Journal of biological chemistry - 25 May 1990

Bird P, Gething M J, Sambrook J

Abstract excerpt

We have previously shown that the signal sequence of the Saccharomyces cerevisiae vacuolar protein carboxypeptidase Y (CPY) does not function in mammalian cells unless a glycine residue in the central core is replaced by leucine. Additional mutants were constructed to investigate the features of this hydrophobic core (h) region that are important for signal sequence function in mammalian cells. We find that the...

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PMID: 2187865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The functional efficiency of a mammalian signal peptide is directly related to its hydrophobicity.PMID 2187865Read ↗

Juxtaposition of signal-peptide charge and core region hydrophobicity is critical for functional signal peptides.Semantic proximity Read ↗

The amino-terminal charge and core region hydrophobicity interdependently contribute to the function of signal sequences.Semantic proximity Read ↗

Polymeric sequences reveal a functional interrelationship between hydrophobicity and length of signal peptides.Semantic proximity Read ↗

Signal peptides: exquisitely designed transport promoters.Semantic proximity Read ↗

Requirement of the propeptide for in vivo formation of active yeast carboxypeptidase Y.Semantic proximity Read ↗

Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids.Semantic proximity Read ↗

Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide.Semantic proximity Read ↗

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function.Semantic proximity Read ↗

Mutations eliminating the protein export function of a membrane-spanning sequence.Semantic proximity Read ↗

Mutational analysis of a signal sequence required for protein secretion in Leishmania major.Semantic proximity Read ↗

Functional asymmetry within the Sec61p translocon.Semantic proximity Read ↗

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