The functional efficiency of a mammalian signal peptide is directly related to its hydrophobicity.

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Article

The functional efficiency of a mammalian signal peptide is directly related to its hydrophobicity.

The Journal of biological chemistry - 25 May 1990

Bird P, Gething M J, Sambrook J

Abstract excerpt

We have previously shown that the signal sequence of the Saccharomyces cerevisiae vacuolar protein carboxypeptidase Y (CPY) does not function in mammalian cells unless a glycine residue in the central core is replaced by leucine. Additional mutants were constructed to investigate the features of...

Topics

Amino Acid Sequence
Animals
Carboxypeptidases
Cathepsin A
Cell Line
Molecular Sequence Data
Mutation
Protein Conformation
Protein Sorting Signals
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Homology, Nucleic Acid
Structure-Activity Relationship
Transfection
Vacuoles

Source

Open in PubMed

Identifiers

PMID: 2187865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2187865-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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