Article
Role of the proregion in the production and secretion of the Yarrowia lipolytica alkaline extracellular protease.
The Journal of biological chemistry - 25 Feb 1991
Fabre E, Nicaud J M, Lopez M C, Gaillardin C
Abstract excerpt
The yeast Yarrowia lipolytica secretes an alkaline extracellular protease (AEP). It is first synthesized as a precursor comprising a putative signal peptide, a stretch of 10 X-Ala or X-Pro sequences that are substrates for a dipeptidyl aminopeptidase, a large pro-region that contains a glycosylation site and two Lys-Arg sites that can be cleaved by a KEX2-like endoprotease and finally the mature protease itself....
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