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Article

The propeptide is required for in vivo formation of stable active yeast proteinase A and can function even when not covalently linked to the mature region.

The Journal of biological chemistry - 25 Aug 1993

van den Hazel H B, Kielland-Brandt M C, Winther J R

Abstract excerpt

The PEP4-encoded aspartate protease proteinase A from Saccharomyces cerevisiae is synthesized as a zymogen (Ammerer, G., Hunter, C. P., Rothman, J. H., Saari, G. C., Valls, L. A., and Stevens, T. H. (1986) Mol. Cell. Biol. 6, 2490-2499; Woolford, C. A., Daniels, L. B., Park, F. J., Jones, E. W., van Arsdell, J. N., and Innis, M. A. (1986) Mol. Cell. Biol. 6, 2500-2510). We constructed a mutant form, lacking the...

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PMID: 8349680

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