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Article

pH-dependent processing of yeast procarboxypeptidase Y by proteinase A in vivo and in vitro.

European journal of biochemistry - 15 Feb 1994

Sørensen S O, van den Hazel H B, Kielland-Brandt M C, Winther J R

Abstract excerpt

Carboxypeptidase Y is a vacuolar enzyme from Saccharomyces cerevisiae. It enters the vacuole as a zymogen, procarboxypeptidase Y, which is immediately processed in a reaction involving two endoproteases, proteinase A and proteinase B. We have investigated the in vitro activation of purified procarboxypeptidase Y by purified proteinase A. This has identified two different processing intermediates; one active and...

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PMID: 8119286
DOI: 10.1111/j.1432-1033.1994.tb18594.x

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