Article
Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast.
European journal of biochemistry - 1 Dec 1993
Finger A, Knop M, Wolf D H
Abstract excerpt
The fate of a mutant form of each of the two yeast vacuolar enzymes proteinase yscA (PrA) and carboxypeptidase yscY (CPY) has been investigated. Both mutant proteins are rapidly degraded after entering the secretory pathway. Mutant PrA is deleted in 37 amino acids spanning the processing site reg...
Topics
- Adenosine Triphosphatases
- Amino Acids
- Aspartic Acid Endopeptidases
- Carboxypeptidases
- Cathepsin A
- Cysteine Endopeptidases
- DNA Mutational Analysis
- Endoplasmic Reticulum
- Enzyme Precursors
- Fluorescent Antibody Technique
- Fungal Proteins
- Kinetics
- Mannose
- Multienzyme Complexes
- Mutation
- Proteasome Endopeptidase Complex
- Protein Processing, Post-Translational
- Saccharomyces cerevisiae