Article
The unfolded-protein-response element discriminates misfolding induced by different mutant pro-sequences of yeast carboxypeptidase Y.
Biochemical and biophysical research communications - 6 Apr 1995
Chaudhuri B, Delany N S, Stephan C
Abstract excerpt
The C-terminal region of the chaperone-like pro-sequence (py) of yeast carboxypeptidase Y (CPY) is suggested to be crucial for the folding of mature CPY. In order to study the influence of hydrophobic residues in this domain, a set of mutations have been introduced in py. Unexpectedly, only small...
Topics
- Base Sequence
- Carboxypeptidases
- Cathepsin A
- DNA Primers
- Endoplasmic Reticulum
- Enzyme Precursors
- Fungal Proteins
- Glycosylation
- HSP70 Heat-Shock Proteins
- Molecular Sequence Data
- Mutation
- Protein Folding
- Saccharomyces cerevisiae
- Tunicamycin