Article
Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4.
Molecular and cellular biology - 1 Nov 2008
Zhang Fan, Gaur Naseem A, Hasek Jiri, Kim Soon-ja, Qiu Hongfang, Swanson Mark J, Hinnebusch Alan G
Abstract excerpt
The late endosome (MVB) plays a key role in coordinating vesicular transport of proteins between the Golgi complex, vacuole/lysosome, and plasma membrane. We found that deleting multiple genes involved in vesicle fusion at the MVB (class C/D vps mutations) impairs transcriptional activation by Gcn4, a global regulator of amino acid biosynthetic genes, by decreasing the ability of chromatin-bound Gcn4 to stimulate...
Topics
- Basic-Leucine Zipper Transcription Factors
- Chromatin
- DNA-Binding Proteins
- Endosomes
- Gene Deletion
- Golgi Apparatus
- Herpes Simplex Virus Protein Vmw65
- Membrane Fusion
- Models, Biological
- Phenotype
- Protein Transport
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae