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Article

Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4.

Molecular and cellular biology - 1 Nov 2008

Zhang Fan, Gaur Naseem A, Hasek Jiri, Kim Soon-ja, Qiu Hongfang, Swanson Mark J, Hinnebusch Alan G

Abstract excerpt

The late endosome (MVB) plays a key role in coordinating vesicular transport of proteins between the Golgi complex, vacuole/lysosome, and plasma membrane. We found that deleting multiple genes involved in vesicle fusion at the MVB (class C/D vps mutations) impairs transcriptional activation by Gcn4, a global regulator of amino acid biosynthetic genes, by decreasing the ability of chromatin-bound Gcn4 to stimulate...

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Identifiers

PMID: 18794364
DOI: 10.1128/MCB.00800-08
PMCID: PMC2573301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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