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Article

Vacuolar and extracellular maturation of Saccharomyces cerevisiae proteinase A.

Yeast (Chichester, England) - 1 Jul 1996

Wolff A M, Din N, Petersen J G

Abstract excerpt

The vacuolar aspartyl protease proteinase A (PrA) of Saccharomyces cerevisiae is encoded as a preproenzyme by the PEP4 gene and transported to the vacuole via the secretory route. Upon arrival of the proenzyme proPrA to the vacuole, active mature 42 kDa PrA is generated by specific proteolysis involving the vacuolar endoprotease proteinase B (PrB). Vacuolar activation of proPrA can also take place in mutants...

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Identifiers

PMID: 8840499
DOI: 10.1002/(SICI)1097-0061(199607)12:9%3C823::AID-YEA975%3E3.0.CO;2-J

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Source receipt: pubmed, retrieved 7 Sept 2026.

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