Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeast.

The Journal of biological chemistry - 18 Jul 2008

Martínez-Muñoz Gloria A, Kane Patricia

Abstract excerpt

Vacuolar proton-translocating ATPases (V-ATPases) play a central role in organelle acidification in all eukaryotic cells. To address the role of the yeast V-ATPase in vacuolar and cytosolic pH homeostasis, ratiometric pH-sensitive fluorophores specific for the vacuole or cytosol were introduced into wild-type cells and vma mutants, which lack V-ATPase subunits. Transiently glucose-deprived wild-type cells respond...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosol
Share to Enzyme Inhibitors
Share to Homeostasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Macrolides

Share to Protons

Share to Vacuolar Proton-Translocating ATPases

Share to Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 18502746
DOI: 10.1074/jbc.M710470200
PMCID: PMC2459297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeast.PMID 18502746Read ↗

Consequences of loss of Vph1 protein-containing vacuolar ATPases (V-ATPases) for overall cellular pH homeostasis.Semantic proximity Read ↗

Regulation of vacuolar proton-translocating ATPase activity and assembly by extracellular pH.Semantic proximity Read ↗

Loss of vacuolar H+-ATPase activity in organelles signals ubiquitination and endocytosis of the yeast plasma membrane proton pump Pma1p.Semantic proximity Read ↗

Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.Semantic proximity Read ↗

Compensatory Internalization of Pma1 in V-ATPase Mutants in Saccharomyces cerevisiae Requires Calcium- and Glucose-Sensitive Phosphatases.Semantic proximity Read ↗

Diploids heterozygous for a vma13Delta mutation in Saccharomyces cerevisiae highlight the importance of V-ATPase subunit balance in supporting vacuolar acidification and silencing cytosolic V1-ATPase activity.Semantic proximity Read ↗

PI(3,5)P2 controls vacuole potassium transport to support cellular osmoregulation.Semantic proximity Read ↗

Role of vacuolar acidification in protein sorting and zymogen activation: a genetic analysis of the yeast vacuolar proton-translocating ATPase.Semantic proximity Read ↗

The long physiological reach of the yeast vacuolar H+-ATPase.Semantic proximity Read ↗

Characterization of Schizosaccharomyces pombe mutants defective in vacuolar acidification and protein sorting.Semantic proximity Read ↗

Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p).Semantic proximity Read ↗

A genomic screen for yeast vacuolar membrane ATPase mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.