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Article

Autoactivation of proteinase A initiates activation of yeast vacuolar zymogens.

European journal of biochemistry - 1 Jul 1992

van den Hazel H B, Kielland-Brandt M C, Winther J R

Abstract excerpt

The Saccharomyces cerevisiae PEP4 gene encodes proteinase A, an aspartyl protease. pep4 mutants are defective in the activation of many vacuolar hydrolases, including proteinase B. We have expressed a pep4 mutation which directs the accumulation of pro-proteinase A with a defective active site. Co-expression with PEP4 leads to normal processing, i.e. the mutant zymogen is functional as a substrate for the...

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PMID: 1628653
DOI: 10.1111/j.1432-1033.1992.tb17048.x

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