Random substitution of large parts of the propeptide of yeast proteinase A.

doi:10.1074/jbc.270.15.8602

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Article

Random substitution of large parts of the propeptide of yeast proteinase A.

The Journal of biological chemistry - 14 Apr 1995

van den Hazel H B, Kielland-Brandt M C, Winther J R

Abstract excerpt

The yeast aspartic protease, proteinase A, has a 54 amino-acid propeptide, which is removed during activation of the zymogen in the vacuole. Apart from being involved inhibition/activation, the propeptide has been shown to be essential for formation of a stable active enzyme (van den Hazel, H. B....

Topics

Amino Acid Sequence
Aspartic Acid Endopeptidases
Base Sequence
Enzyme Precursors
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Peptide Fragments
Plasmids
Protein Precursors
Protein Processing, Post-Translational
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 7721762
DOI: 10.1074/jbc.270.15.8602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7721762-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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