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Article

Random substitution of large parts of the propeptide of yeast proteinase A.

The Journal of biological chemistry - 14 Apr 1995

van den Hazel H B, Kielland-Brandt M C, Winther J R

Abstract excerpt

The yeast aspartic protease, proteinase A, has a 54 amino-acid propeptide, which is removed during activation of the zymogen in the vacuole. Apart from being involved inhibition/activation, the propeptide has been shown to be essential for formation of a stable active enzyme (van den Hazel, H. B., Kielland-Brandt, M. C., and Winther, J. R. (1993) J. Biol. Chem. 268, 18002-18007). We have investigated the sequence...

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PMID: 7721762
DOI: 10.1074/jbc.270.15.8602

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