A mutant of the WEHI-231 B lymphocyte line that is resistant to phorbol esters is still sensitive to antigen receptor-mediated growth inhibition.

doi:10.1006/cimm.1994.1066

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Article

A mutant of the WEHI-231 B lymphocyte line that is resistant to phorbol esters is still sensitive to antigen receptor-mediated growth inhibition.

Cellular immunology - 1 Mar 1994

Haggerty H G, Monroe J G

Abstract excerpt

In order to gain a better understanding of the pathways linking receptor immunoglobulin (sIg) crosslinking to downstream B lymphocyte responses, mutants were generated that were defective in sIg-associated signaling pathways. The murine B lymphoma WEHI-231 has proven to be a useful model for stud...

Topics

Animals
Antibodies
B-Lymphocytes
Cell Division
Cell Line
Drug Resistance
Gene Expression
Genes, fos
Immunoglobulin M
Mice
Mutation
Protein Kinase C
Receptors, Fc
Signal Transduction
Tetradecanoylphorbol Acetate

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