Article
Isolation and characterization of cell lines with genetically distinct mutations downstream of protein kinase C that result in defective activation-dependent regulation of T cell integrin function.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1996
Mobley J L, Ennis E, Shimizu Y
Abstract excerpt
beta 1-integrins expressed on resting T cells support only minimal adhesion to integrin ligands. T cell activation through multiple stimuli, including phorbol ester treatment and Ab cross-linking of the CD3/TCR complex, results in a rapid and transient switch in integrin function from low to high...
Topics
- CD18 Antigens
- Cell Adhesion
- Cell Separation
- Gene Expression Regulation, Neoplastic
- Genetic Complementation Test
- Humans
- Integrin beta1
- Integrins
- Interleukin-2
- Lymphocyte Activation
- Lymphoma, T-Cell
- Mutation
- Protein Kinase C
- Protein Kinases
- Tumor Cells, Cultured