Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor.

doi:10.1093/emboj/16.11.3078

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor.

The EMBO journal - 2 Jun 1997

Sugawara H, Kurosaki M, Takata M, Kurosaki T

Abstract excerpt

Stimulation of B-cell antigen receptor (BCR) induces a rapid increase in cytoplasmic free calcium due to its release from intracellular stores and influx from the extracellular environment. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ligand-gated channels that release intracellular calcium stores in response to the second messenger, inositol 1,4,5-trisphosphate. Most hematopoietic cells, including B cells,...

Topics

Biological Transport
Calcium
Calcium Channels
Cell Line
Enzyme Activation
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Intracellular Signaling Peptides and Proteins
Isoenzymes
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Myristoylated Alanine-Rich C Kinase Substrate

Phospholipase C gamma

Proteins

Receptor, Muscarinic M1

Receptors, Antigen, B-Cell

Receptors, Cytoplasmic and Nuclear

Receptors, Muscarinic

Source

Open in PubMed Open full text

Identifiers

PMID: 9214625
DOI: 10.1093/emboj/16.11.3078
PMCID: PMC1169926

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9214625-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor.PMID 9214625Read ↗

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis.Semantic proximity Read ↗

Disrupted Ca<sup>2+</sup> homeostasis and immunodeficiency in patients with functional Inositol 1,4,5-trisphosphate receptor subtype 3 defectsSemantic proximity Read ↗

Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defectsSemantic proximity Read ↗

T-cell-receptor signalling in inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice: is IP3R type 1 essential for T-cell-receptor signalling?Semantic proximity Read ↗

B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.Semantic proximity Read ↗

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.Semantic proximity Read ↗

Fc gamma RIIB activation leads to inhibition of signalling by independently ligated receptors.Semantic proximity Read ↗

Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes.Semantic proximity Read ↗

Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement.Semantic proximity Read ↗

Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes.Semantic proximity Read ↗

A mutant of the WEHI-231 B lymphocyte line that is resistant to phorbol esters is still sensitive to antigen receptor-mediated growth inhibition.Semantic proximity Read ↗

A new splice variant of the inositol-1,4,5-triphosphate (IP3) receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.