Article
Antigen receptor-initiated growth inhibition is blocked in CD45-loss variants of a mature B lymphoma, with limited effects on apoptosis.
European journal of immunology - 1 Aug 1995
Ogimoto M, Katagiri T, Mashima K, Hasegawa K, Mizuno K, Yakura H
Abstract excerpt
Role of CD45 in B cell antigen receptor (BcR)-mediated signaling events in mature B cells was examined using BAL-17 and its CD45-negative clones. In the CD45-negative clones, BcR stimulation induced tyrosine phosphorylation almost identical to the parental cells, with a few exceptions of reduced phosphorylation, especially of a protein of about 60 kDa. BcR-induced calcium responses were reduced in the...
Topics
- Animals
- Apoptosis
- B-Lymphocytes
- Calcium
- Cell Death
- Cell Line
- Genetic Variation
- Leukocyte Common Antigens
- Lymphoma, B-Cell
- Mice
- Protein Tyrosine Phosphatases