Article
Possible association of p53 overexpression and mutation with high-grade chondrosarcoma.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Dec 1993
Dobashi Y, Sugimura H, Sato A, Hirabayashi T, Kanda H, Kitagawa T, Kawaguchi N, Imamura T, Machinami R
Abstract excerpt
Overexpression and point mutation of the p53 protein/gene was investigated in a series of chondrosarcoma by an immunohistochemical approach, and direct sequencing of the genomic DNA, respectively. In 2 of the 16 cases studied, both of which were high grade chondrosarcomas (grade III), immunodetectable p53 was identified. Histologically, one was ordinary type and the other a clear cell variant. However, no...
Topics
- Adult
- Aged
- Arginine
- Base Sequence
- Bone Neoplasms
- Chondrosarcoma
- DNA, Neoplasm
- Exons
- Female
- Genes, p53
- Histidine