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Article

Mutation spectrum of p53 gene in highly malignant human osteosarcomas.

General & diagnostic pathology - 1 Jun 1996

Radig K, Schneider-Stock R, Oda Y, Neumann W, Mittler U, Roessner A

Abstract excerpt

In this study, we analyzed the spectrum of p53 tumor suppressor gene mutations in 40 highly malignant osteosarcomas, one osteosarcoma metastasis, and one osteoblastoma with malignant transformation. Using predominantly formalin-fixed and paraffin-embedded material, we performed polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of exons 4-8 and direct sequencing. Molecular...

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PMID: 8793483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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