Article
Overexpression of p53 and rare genetic mutation in mesenchymal chondrosarcoma.
Oncology reports - 1 Jan 2000
Park Y K, Park H R, Chi S G, Kim C J, Sohn K R, Koh J S, Kim C W, Yang W I, Ro J Y, Ahn K W, Joo M, Kim Y W, Lee J, Yang M H, Unni K K
Abstract excerpt
Mesenchymal chondrosarcoma is extremely rare and accounts for less than 2% of all chondrosarcomas. The pathogenesis and the molecular genetic events which contribute to the development of mesenchymal chondrosarcoma are not well elucidated, due in part to the lack of sufficient tumor tissue available. To characterize the involvement of the p53 gene abnormality in this disease, we analyzed expression and sequence...
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