p53 abnormalities in different subtypes of human sarcomas.

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Article

p53 abnormalities in different subtypes of human sarcomas.

Cancer research - 1 Feb 1993

Andreassen A, Oyjord T, Hovig E, Holm R, Flørenes V A, Nesland J M, Myklebost O, Høie J, Bruland O S, Børresen A L

Abstract excerpt

In this report we examined p53 alterations at the DNA, mRNA, and protein levels on tissue from 39 patients with different subtypes of sarcoma. Loss of heterozygosity for the chromosome 17p region was found in 60, 63, and 33% of 10 informative osteosarcomas, 11 malignant fibrous histiocytomas, and...

Topics

Base Sequence
Chromosome Aberrations
Chromosomes, Human, Pair 17
DNA, Neoplasm
Exons
Gene Expression
Genes, p53
Heterozygote
Humans
Molecular Sequence Data
Mutation
RNA, Messenger
Sarcoma
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8425179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8425179-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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