p53 gene mutations in osteosarcomas of low-grade malignancy.

doi:10.1016/s0046-8177(98)90263-5

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Article

p53 gene mutations in osteosarcomas of low-grade malignancy.

Human pathology - 1 Nov 1998

Radig K, Schneider-Stock R, Haeckel C, Neumann W, Roessner A

Abstract excerpt

Alterations in tumor suppressor gene p53, localized on chromosome 17p13, are considered to play a significant role in the initiation and, to some extent, even in the progression of various malignant tumors. In this respect, investigations on conventional highly malignant osteosarcomas have shown...

Topics

Adolescent
Adult
Aged
Bone Neoplasms
Child
DNA, Neoplasm
Female
Genes, p53
Humans
Immunoenzyme Techniques
Male
Middle Aged
Mutation
Osteosarcoma
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Tumor Suppressor Protein p53

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