Article
[Study on the expression of epidermal growth factor receptor and p53 in astrocytic gliomas: evidence for a distinct genetic pathway].
Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Apr 2006
Dong Lun, Pu Pei-yu, Wang Hu, Wang Guang-xiu, Kang Chun-sheng, Jiao De-rang
Abstract excerpt
OBJECTIVE: To study further the most important and frequent genetic alterations of p53 and epidermal growth factor receptor (EGFR) in astrocytic gliomas. METHODS: (1) EGFR expression was examined in samples collected from 37 astrocytic gliomas and 6 normal brain tissue using reverse transcriptase polymerase chain reaction and immunohistochemical staining. (2) p53 gene mutation and accumulation were detected...
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