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Detection of P53 mutations in different cancer types is improved by cDNA sequencing

4 Jun 2010

Abstract excerpt

Recently published data show discrepancies between P53 cDNA and DNA sequencing results in glioblastoma, colorectal cancer and pleomorphic xanthoastrocytoma. We hypothesized that similar discrepancies are observed in other types of human cancers. Using DNA and cDNA direct sequencing, we analyzed 40 cases of invasive breast duct carcinoma, 23 cases of acute myeloblastic leukaemia, 12 cases of astrocytoma and 40...

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PMID: 22966368
DOI: 10.3892/ol_00000125

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