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Article

cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer.

BMC cancer - 11 Aug 2009

Szybka Malgorzata, Zakrzewska Magdalena, Rieske Piotr, Pasz-Walczak Grazyna, Kulczycka-Wojdala Dominika, Zawlik Izabela, Stawski Robert, Jesionek-Kupnicka Dorota, Liberski Pawel P, Kordek Radzislaw

Abstract excerpt

BACKGROUND: Recently published data showed discrepancies between P53 cDNA and DNA sequencing in glioblastomas. We hypothesised that similar discrepancies may be observed in other human cancers. METHODS: To this end, we analyzed 23 colorectal cancers for P53 mutations and gene expression using both DNA and cDNA sequencing, real-time PCR and immunohistochemistry. RESULTS: We found P53 gene mutations in 16 cases (15...

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Source

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Identifiers

PMID: 19671129
DOI: 10.1186/1471-2407-9-278
PMCID: PMC2731783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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