Article
An amino acid change in the non-structural NS2 protein of an influenza A virus mutant is responsible for the generation of defective interfering (DI) particles by amplifying DI RNAs and suppressing complementary RNA synthesis.
The Journal of general virology - 1 Jan 1994
Odagiri T, Tominaga K, Tobita K, Ohta S
Abstract excerpt
The mutated non-structural NS2 protein of an influenza A virus mutant, Wa-182, has been shown to be responsible for the production of defective interfering (DI) particles lacking the PA gene after a single cycle high-multiplicity infection. Using a subclone of Wa-182, A3/e-3, that inherited the W...
Topics
- Cell Line
- DNA Replication
- DNA-Directed RNA Polymerases
- Defective Viruses
- Gene Amplification
- Influenza A virus
- Molecular Sequence Data
- Mutation
- Phenotype
- RNA, Complementary
- RNA, Viral
- RNA-Dependent RNA Polymerase
- Serial Passage
- Structure-Activity Relationship