Replication Signals in the Genome of Vesicular Stomatitis Virus and Its Defective Interfering Particles: Identification of a Sequence Element That Enhances DI RNA Replication

Abstract excerpt

We have analyzed the role of terminal sequences of a defective interfering (DI) particle RNA of vesicular stomatitis virus (VSV) in replication. A series of internal deletion mutants of DI cDNA was generated to obtain DI genomic RNAs that differed from one another by the presence of different lengths of 3'-terminal and/or 5'-terminal sequences. Analyses of the mutant. RNAs for their ability to replicate in cells...

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