Article
Mutation in NS2, a nonstructural protein of influenza A virus, extragenically causes aberrant replication and expression of the PA gene and leads to generation of defective interfering particles.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Odagiri T, Tobita K
Abstract excerpt
Several consecutive undiluted passages of infectious virus are usually required to obtain defective interfering particles of influenza virus. In contrast, a reassortant (Wa-182) of influenza A/WSN, which we isolated, whose NS gene was replaced with the NS gene of A/Aichi, was readily converted to defective interfering form after only a single high-multiplicity infection. The defective interfering particles of...
Topics
- Animals
- Base Sequence
- Capsid
- Cell Line
- Cloning, Molecular
- DNA-Directed RNA Polymerases
- Defective Viruses
- Gene Expression
- Genes, Viral
- Hemagglutinins, Viral