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Article

Defective interfering viruses and their potential as antiviral agents

29 Dec 2009

Abstract excerpt

Defective interfering (DI) virus is simply defined as a spontaneously generated virus mutant from which a critical portion of the virus genome has been deleted. At least one essential gene of the virus is deleted, either in its entirety, or sufficiently to make it non-functional. The resulting DI genome is then defective for replication in the absence of the product(s) of the deleted gene(s), and its replication...

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PMID: 20041441
DOI: 10.1002/rmv.641

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