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Article

Involvement of the influenza A virus PB2 protein in the regulation of viral gene expression.

The Journal of general virology - 1 Nov 1991

Mukaigawa J, Hatada E, Fukuda R, Shimizu K

Abstract excerpt

To determine the function(s) of the PB2 protein of influenza A virus, six temperature-sensitive (ts) mutants of A/Udorn/72 (H3N2) virus, each carrying a ts mutation in the PB2 gene, were analysed for virus RNA and protein synthesis. One of the mutants, ICRC27, exhibited unique phenotypes and was characterized in detail. At the non-permissive temperature, 40 degrees C, the accumulation of mRNA for each genome...

Topics

Cycloheximide
DNA-Directed RNA Polymerases
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation, Viral
Influenza A virus
Kinetics
Mutation
RNA, Viral
RNA-Dependent RNA Polymerase
Temperature
Viral Proteins

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Identifiers

PMID: 1940863
DOI: 10.1099/0022-1317-72-11-2661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1940863-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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