Article
Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles.
Journal of virology - 1 May 2002
Kümmerer Beate M, Rice Charles M
Abstract excerpt
Little is known about the function of flavivirus nonstructural protein NS2A. Two forms of NS2A are found in yellow fever virus-infected cells. Full-length NS2A (224 amino acids) is the product of cleavage at the NS1/2A and NS2A/2B sites. NS2Aalpha, a C-terminally truncated form of 190 amino acids, results from partial cleavage by the viral NS2B-3 serine protease at the sequence QK /T within NS2A. Exchange of...
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