Article
Aichi virus 2A protein is involved in viral RNA replication.
Journal of virology - 1 Oct 2008
Sasaki Jun, Taniguchi Koki
Abstract excerpt
The Aichi virus 2A protein is not a protease, unlike many other picornavirus 2A proteins, and it is related to a cellular protein, H-rev107. Here, we examined the replication properties of two 2A mutants in Vero cells and a cell-free translation/replication system. In one mutant, amino acids 36 to 126 were replaced with an unrelated amino acid sequence. In the other mutant, the NC motif conserved in the H-rev107...
Topics
- Amino Acids
- Animals
- Cell-Free System
- Chlorocebus aethiops
- DNA, Complementary
- Gene Expression Regulation, Viral
- Kobuvirus
- Models, Biological
- Models, Genetic
- Mutation
- Protein Biosynthesis
- RNA, Viral
- Vero Cells
- Virus Replication
