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Article

Characterization of functionally important regions of tissue factor by using monoclonal antibodies.

Journal of biochemistry - 1 Nov 1993

Ito T, Hiraiwa J, Nishioka J, Iino M, Suzuki K

Abstract excerpt

Tissue factor is a cellular membrane glycoprotein that acts as a cofactor for Factor VIIa-catalyzed activation of Factors X and IX in the extrinsic blood coagulation pathway. We prepared fourteen murine monoclonal antibodies to human tissue factor (designated MTF-1 to -14), and purified tissue factor from human placenta by immunoaffinity chromatography using the antibody-coupled Sepharose 4B. The antibodies were...

Topics

Animals
Antibodies, Monoclonal
Binding Sites
Blotting, Western
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Factor VIIa
Factor X
Humans
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phospholipids

Placenta

Thromboplastin

Source

Identifiers

PMID: 8113222
DOI: 10.1093/oxfordjournals.jbchem.a124238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8113222-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of functionally important regions of tissue factor by using monoclonal antibodies.PMID 8113222Read ↗

Structural biology of tissue factor, the initiator of thrombogenesis in vivo 1Semantic proximity Read ↗

Immunological and functional analyses of the extracellular domain of human tissue factor.Semantic proximity Read ↗

Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies.Semantic proximity Read ↗

Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity.Semantic proximity Read ↗

Modulation of TAFI function through different pathways--implications for the development of TAFI inhibitors.Semantic proximity Read ↗

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Monoclonal antibodies for human thrombomodulin which recognize binding sites for thrombin and protein C.Semantic proximity Read ↗

Enhancing the anticoagulant potency of soluble tissue factor mutants by increasing their affinity to factor VIIa.Semantic proximity Read ↗

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