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Article

Modulation of TAFI function through different pathways--implications for the development of TAFI inhibitors.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2005

Gils A, Ceresa E, Macovei A M, Marx P F, Peeters M, Compernolle G, Declerck P J

Abstract excerpt

OBJECTIVE: To elucidate the mechanism and the binding regions of monoclonal antibodies (MA) that interfere with thrombin-activatable fibrinolysis inhibitor (TAFI)/activated thrombin-activatable fibrinolysis inhibitor (TAFIa) activity. RESULTS: Of 42 MA, 19 interfere with the TAFI activation/TAFIa activity resulting in an inhibition of up to 92%. Characterization of the mechanism of inhibition revealed that 14 MA...

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Source

Identifiers

PMID: 16359512
DOI: 10.1111/j.1538-7836.2005.01629.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulation of TAFI function through different pathways--implications for the development of TAFI inhibitors.PMID 16359512Read ↗

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