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Article

Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies.

Thrombosis and haemostasis - 1 Dec 2000

Kirchhofer D, Moran P, Chiang N, Kim J, Riederer M A, Eigenbrot C, Kelley R F

Abstract excerpt

Tissue factor (TF), the cellular cofactor for the serine protease factor VIIa (F.VIIa), triggers blood coagulation and is involved in the pathogenesis of various thrombosis-related disorders. Therefore, agents which specifically target tissue factor, such as monoclonal antibodies, may provide promising new antithrombotic therapy. We mapped the epitopes of several anti-TF antibodies using a panel of soluble TF...

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PMID: 11154116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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