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Article

Tissue factor pathway inhibitor binds to platelet thrombospondin-1.

The Journal of biological chemistry - 13 Oct 2000

Mast A E, Stadanlick J E, Lockett J M, Dietzen D J, Hasty K A, Hall C L

Abstract excerpt

Tissue factor pathway inhibitor (TFPI) is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. The most biologically active pool of TFPI is associated with the vascular endothelium, however, the biochemical mechanisms responsible for its cellular binding are not entirely defined. Proposed cellular binding sites for TFPI include nonspecific association with cell...

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Source

Identifiers

PMID: 10922378
DOI: 10.1074/jbc.M006595200

Genes

TFPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Tissue factor pathway inhibitor binds to platelet thrombospondin-1.PMID 10922378Read ↗

Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma.Semantic proximity Read ↗

New insights into the biology of tissue factor pathway inhibitor.Semantic proximity Read ↗

Structure, function and biology of tissue factor pathway inhibitor-2Semantic proximity Read ↗

Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitisSemantic proximity Read ↗

Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant ActivitySemantic proximity Read ↗

Inhibitory effects of TFPI variants on thrombin and factor Xa generation in fibrinogen-deficient human plasma.Semantic proximity Read ↗

Tissue factor pathway inhibitor relates to fibrin degradation in patients with acute deep venous thrombosis.Semantic proximity Read ↗

Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.Semantic proximity Read ↗

Antibodies against TFPI and protein C are associated with a severe thrombotic phenotype in patients with and without antiphospholipid syndrome.Semantic proximity Read ↗

Domain V of beta2-glycoprotein I binds factor XI/XIa and is cleaved at Lys317-Thr318.Semantic proximity Read ↗

Plasmin-mediated cleavage of GPIbα contributes to breakdown of platelet-von Willebrand factor complexesSemantic proximity Read ↗

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.Semantic proximity Read ↗

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