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Article

Activation of a recombinant human factor VII structural analogue alters its affinity of binding to tissue factor.

American journal of hematology - 1 Oct 1996

Sridhara S, Chaing S, High K A, Blajchman M A, Clarke B J

Abstract excerpt

A competitive enzyme-linked immunoadsorbent assay (ELISA) technique has been developed to facilitate quantitative analysis of the earliest step in the initiation of the extrinsic pathway of coagulation, i.e., complex formation of factor VII/VIIa with tissue factor. The ELISA measures the binding of biotinylated human plasma factor VII to relipidated recombinant human tissue factor. Quantitation of the relative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8892729
DOI: 10.1002/(SICI)1096-8652(199610)53:2<66::AID-AJH2>3.0.CO;2-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of a recombinant human factor VII structural analogue alters its affinity of binding to tissue factor.PMID 8892729Read ↗

Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor.Semantic proximity Read ↗

Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function.Semantic proximity Read ↗

Cofactor-induced and mutational activity enhancement of coagulation factor VIIa.Semantic proximity Read ↗

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.Semantic proximity Read ↗

Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation.Semantic proximity Read ↗

Variants of recombinant factor VIIa with increased intrinsic activity.Semantic proximity Read ↗

Molecular interaction between factor VII and tissue factor.Semantic proximity Read ↗

Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity.Semantic proximity Read ↗

Large enhancement of functional activity of active site-inhibited factor VIIa due to protein dimerization: insights into mechanism of assembly/disassembly from tissue factor.Semantic proximity Read ↗

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.Semantic proximity Read ↗

Enhancing the anticoagulant potency of soluble tissue factor mutants by increasing their affinity to factor VIIa.Semantic proximity Read ↗

Surface loop 199-204 in blood coagulation factor IX is a cofactor-dependent site involved in macromolecular substrate interaction.Semantic proximity Read ↗

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