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Article

Enhancing the anticoagulant potency of soluble tissue factor mutants by increasing their affinity to factor VIIa.

Thrombosis and haemostasis - 1 Mar 2002

Yang Jihong, Lee Geoffrey F, Riederer Markus A, Kelley Robert F

Abstract excerpt

Complexation of factor VIIa (FVIIa) and tissue factor (TF) initiates the extrinsic pathway of blood coagulation. Inappropriate triggering of this pathway has been linked to thrombotic disorders. We have previously shown that a mutant form ofsoluble tissue factor (sTF, residues 1-219) having Lys165 and Lys166 replaced with alanine residues (hTFAA) gave an antithromboticeffect in a rabbit model of arterial...

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PMID: 11916078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhancing the anticoagulant potency of soluble tissue factor mutants by increasing their affinity to factor VIIa.PMID 11916078Read ↗

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Structural biology of tissue factor, the initiator of thrombogenesis in vivo 1Semantic proximity Read ↗

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