Article
Monoclonal antibodies for human thrombomodulin which recognize binding sites for thrombin and protein C.
Journal of biochemistry - 1 Nov 1990
Hayashi T, Suzuki K
Abstract excerpt
Monoclonal antibodies for human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C, were prepared and their epitopes characterized. All six antibodies (MFTM-1-MFTM-6) bound to an elastase-digested active fragment of thrombomodulin, which contains six consecutive EGF domains. Binding of thrombomodulin to these antibodies did not depend on Ca2+ concentration. MFTM-4, MFTM-5, and MFTM-6...
Topics
- 1-Carboxyglutamic Acid
- Antibodies, Monoclonal
- Binding Sites
- Binding, Competitive
- Calcium
- Epidermal Growth Factor
- Humans
- Mutation
- Protein C
- Receptors, Cell Surface
- Receptors, Thrombin