Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule.

Thrombosis and haemostasis - 1 Jul 1999

Bromberg M E, Sundaram R, Homer R J, Garen A, Konigsberg W H

Abstract excerpt

Tissue factor (TF) is a transmembrane glycoprotein that complexes with factor VIIa to initiate blood coagulation. It was reported in an earlier study that expression of high levels of TF in a human melanoma cell line promotes metastasis, and that the cytoplasmic domain of TF is required for this metastatic effect. To analyze the functions of the cytoplasmic and extracellular domains of TF in metastasis, two TF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Neoplastic
Share to Melanoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Neoplasm Metastasis

Share to Rabbits

Share to Thromboplastin

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10456459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule.PMID 10456459Read ↗

Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.Semantic proximity Read ↗

Tissue Factor and Cancer Metastasis: The Role of Intracellular and Extracellular Signaling PathwaysSemantic proximity Read ↗

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.Semantic proximity Read ↗

Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin.Semantic proximity Read ↗

Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders.Semantic proximity Read ↗

Characterization of functionally important regions of tissue factor by using monoclonal antibodies.Semantic proximity Read ↗

Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.Semantic proximity Read ↗

Immunological and functional analyses of the extracellular domain of human tissue factor.Semantic proximity Read ↗

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.Semantic proximity Read ↗

Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice.Semantic proximity Read ↗

Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.