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Article

Molecular interaction between factor VII and tissue factor.

International journal of hematology - 1 Apr 1998

Higashi S, Iwanaga S

Abstract excerpt

Complex formation between serine protease factor VIIa (VIIa) and tissue factor (TF) dramatically enhances the catalytic activity of VIIa, leading to the initiation of extrinsic blood coagulation. The recently determined crystal structure of the complex formed between VIIa and the extracellular domain of TF has revealed in detail the interacting surfaces of the two molecules. Mutational and biochemical studies...

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Source

Identifiers

PMID: 9650444
DOI: 10.1016/s0925-5710(98)00018-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Click a neighbor to travelStep 1 · 12 closest

Molecular interaction between factor VII and tissue factor.PMID 9650444Read ↗

Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor.VIIa with Xa.tissue factor pathway inhibitor.Semantic proximity Read ↗

Cofactor-induced and mutational activity enhancement of coagulation factor VIIa.Semantic proximity Read ↗

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.Semantic proximity Read ↗

Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation.Semantic proximity Read ↗

The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII--tissue factor complex.Semantic proximity Read ↗

In vivo activation and functions of the protease factor XIISemantic proximity Read ↗

Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa.Semantic proximity Read ↗

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.Semantic proximity Read ↗

Large enhancement of functional activity of active site-inhibited factor VIIa due to protein dimerization: insights into mechanism of assembly/disassembly from tissue factor.Semantic proximity Read ↗

Four loops of the catalytic domain of factor viia mediate the effect of the first EGF-like domain substitution on factor viia catalytic activity.Semantic proximity Read ↗

Structural biology of tissue factor, the initiator of thrombogenesis in vivo 1Semantic proximity Read ↗

Tissue Factor residue Asp44 regulates catalytic function of the bound proteinase Factor VIIa.Semantic proximity Read ↗

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