Molecular interaction between factor VII and tissue factor.

doi:10.1016/s0925-5710(98)00018-8

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Article

Molecular interaction between factor VII and tissue factor.

International journal of hematology - 1 Apr 1998

Higashi S, Iwanaga S

Abstract excerpt

Complex formation between serine protease factor VIIa (VIIa) and tissue factor (TF) dramatically enhances the catalytic activity of VIIa, leading to the initiation of extrinsic blood coagulation. The recently determined crystal structure of the complex formed between VIIa and the extracellular do...

Topics

Amino Acid Sequence
Animals
Factor VII
Humans
Molecular Sequence Data
Mutation
Protein Binding
Protein Conformation
Structure-Activity Relationship
Thromboplastin

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