Article
Ectopic expression of Hox-2.3 induces craniofacial and skeletal malformations in transgenic mice.
Mechanisms of development - 1 Nov 1992
McLain K, Schreiner C, Yager K L, Stock J L, Potter S S
Abstract excerpt
To better understand the role of the Hox-2.3 murine homeobox gene during development, a dominant gain-of-function mutation was generated. The developmental malformations that resulted when the chicken beta-actin promoter was used to direct widespread expression of the Hox-2.3 gene in transgenic mice included early postnatal death as well as craniofacial abnormalities, including open eyes and cleft palate....
Topics
- Abnormalities, Multiple
- Actins
- Animals
- Animals, Newborn
- Bone and Bones
- Cleft Palate
- Embryonic and Fetal Development
- Eye Abnormalities
- Female
- Gene Expression Regulation
- Genes, Homeobox