Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.

doi:10.1016/0092-8674(94)90069-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.

Cell - 2 Dec 1994

Heasman J, Crawford A, Goldstone K, Garner-Hamrick P, Gumbiner B, McCrea P, Kintner C, Noro C Y, Wylie C

Abstract excerpt

The cadherin-catenin complex has an important role in cell-cell adhesion and may also function in signaling pathways. We report that overexpression of three cadherin types in Xenopus embryos causes them to develop with reduced dorsal axial structures. The same phenotype is produced in embryos tha...

Topics

Animals
Base Sequence
Blastocyst
Blastomeres
Cadherins
Cell Aggregation
Cytoskeletal Proteins
Embryo, Nonmammalian
Embryonic Induction
Immunohistochemistry
Mesoderm
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nervous System

Oocytes

Phenotype

Proto-Oncogene Proteins

RNA

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7528101
DOI: 10.1016/0092-8674(94)90069-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7528101-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.PMID 7528101Read ↗

Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm.Semantic proximity Read ↗

Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin.Semantic proximity Read ↗

Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish.Semantic proximity Read ↗

A role for N-cadherin in mesodermal morphogenesis during gastrulation.Semantic proximity Read ↗

Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes.Semantic proximity Read ↗

Lack of beta-catenin affects mouse development at gastrulation.Semantic proximity Read ↗

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.Semantic proximity Read ↗

The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.Semantic proximity Read ↗

Maternal beta-catenin and E-cadherin in mouse development.Semantic proximity Read ↗

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.Semantic proximity Read ↗

Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.Semantic proximity Read ↗

Ventral neural cadherin, a novel cadherin expressed in a subset of neural tissues in the zebrafish embryo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.