Article
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.
Genes & development - 1 Feb 1996
Greco T L, Takada S, Newhouse M M, McMahon J A, McMahon A P, Camper S A
Abstract excerpt
Mice homozygous for the recessive mutation vestigial tail (vt), which arose spontaneously on Chromosome 11, exhibit vertebral abnormalities, including loss of caudal vertebrae leading to shortening of the tail. Wnt-3a, a member of the wingless family of secreted glycoproteins, maps to the same chromosome. Embryos homozygous for a null mutation in Wnt-3a (Wnt-3a(neo)) have a complete absence of tail bud...
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