In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40 large T antigen mutants.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40 large T antigen mutants.

Oncogene - 1 Mar 1994

Maclean K, Rogan E M, Whitaker N J, Chang A C, Rowe P B, Dalla-Pozza L, Symonds G, Reddel R R

Abstract excerpt

Transfection of SV40 early region DNA into normal human diploid fibroblasts (NHDFs) increases their proliferative potential to a limited extent. We have investigated the roles of the SV40 large T antigen (LTAg) regions responsible for binding to the protein products of the retinoblastoma (Rb) and...

Topics

Antigens, Polyomavirus Transforming
Base Sequence
Cell Transformation, Viral
Cellular Senescence
DNA Primers
Fibroblasts
Genes, p53
Humans
Li-Fraumeni Syndrome
Molecular Sequence Data
Mutation
Sequence Deletion
Transfection
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8108114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8108114-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics