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Article

In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40 large T antigen mutants.

Oncogene - 1 Mar 1994

Maclean K, Rogan E M, Whitaker N J, Chang A C, Rowe P B, Dalla-Pozza L, Symonds G, Reddel R R

Abstract excerpt

Transfection of SV40 early region DNA into normal human diploid fibroblasts (NHDFs) increases their proliferative potential to a limited extent. We have investigated the roles of the SV40 large T antigen (LTAg) regions responsible for binding to the protein products of the retinoblastoma (Rb) and p53 genes in this temporary escape from senescence. Patients encoding LTAg mutants were transfected into NHDFs and...

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PMID: 8108114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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