Article
A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease.
Brain pathology (Zurich, Switzerland) - 1 Jan 2019
Bell W Robert, Meeker Alan K, Rizzo Anthony, Rajpara Sumit, Rosenthal Ian M, Flores Bellver Miguel, Aparicio Domingo Silvia, Zhong Xiufeng, Barber John R, Joshu Corinne E, Canto-Soler M Valeria, Eberhart Charles G, Heaphy Christopher M
Abstract excerpt
We have identified a discrete, focal telomere DNA expansion phenotype in the photoreceptor cell layer of normal, non-neoplastic human retinas. This phenotype is similar to that observed in a subset of human cancers, including a large fraction of tumors of the central nervous system, which maintain their telomeres via the non-telomerase-mediated alternative lengthening of telomeres (ALT) mechanism. We observed...
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