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Article

Analysis of human papillomavirus type 16 open reading frame E7 immortalizing function in rat embryo fibroblast cells.

The Journal of general virology - 1 Feb 1990

Chesters P M, Vousden K H, Edmonds C, McCance D J

Abstract excerpt

The E7 open reading frame of human papillomavirus type 16 (HPV-16) encodes a protein that can immortalize primary rat cells, cooperate with the ras oncoprotein to transform low passage rat cells and transform established rodent cells to anchorage independence. The immortalizing and cooperation functions have been investigated using a series of point mutations that introduce single amino acid changes into the E7...

Topics

Amino Acid Sequence
Animals
Cells, Cultured
Fibroblasts
Molecular Sequence Data
Mutation
Oncogene Proteins, Viral
Papillomaviridae
Papillomavirus E7 Proteins
Rats
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2155297
DOI: 10.1099/0022-1317-71-2-449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2155297-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of human papillomavirus type 16 open reading frame E7 immortalizing function in rat embryo fibroblast cells.PMID 2155297Read ↗

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