A role for both RB and p53 in the regulation of human cellular senescence.

doi:10.1016/0014-4827(91)90453-2

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Article

A role for both RB and p53 in the regulation of human cellular senescence.

Experimental cell research - 1 Sept 1991

Shay J W, Pereira-Smith O M, Wright W E

Abstract excerpt

We present evidence for the possible involvement of both the RB and p53 proteins in the regulation of cellular senescence. Human fibroblasts immortalized with an inducible SV40 T-antigen become senescent following the de-induction of T-antigen. Plasmids expressing an alternative source of intact...

Topics

Adenoviruses, Human
Antigens, Viral, Tumor
Cell Division
Cell Survival
Cells, Cultured
Genes, Viral
Humans
Lung
Mutation
Papillomaviridae
Plasmids
Retinoblastoma Protein
Simian virus 40
Tumor Suppressor Protein p53

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