Article
A role for both RB and p53 in the regulation of human cellular senescence.
Experimental cell research - 1 Sept 1991
Shay J W, Pereira-Smith O M, Wright W E
Abstract excerpt
We present evidence for the possible involvement of both the RB and p53 proteins in the regulation of cellular senescence. Human fibroblasts immortalized with an inducible SV40 T-antigen become senescent following the de-induction of T-antigen. Plasmids expressing an alternative source of intact T-antigen restore proliferation but T-antigen deletion mutants lacking either the RB or p53 binding domains are unable...
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