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Article

Cell cycle arrest defect in Li-Fraumeni Syndrome: a mechanism of cancer predisposition?

Oncogene - 23 Jan 1997

Williams K J, Boyle J M, Birch J M, Norton J D, Scott D

Abstract excerpt

Cancer predisposition in approximately 60% of Li-Fraumeni Syndrome (LFS) families is associated with germline mutation of the TP53 gene. The p53 protein has been shown to mediate G1 arrest following DNA damage. We have investigated gamma-irradiation-induced transient and permanent G1 arrest in normal and LFS fibroblasts. The duration of transient G1 arrest varied between strains, but there was no difference in...

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Identifiers

PMID: 9018113
DOI: 10.1038/sj.onc.1200838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Cell cycle arrest defect in Li-Fraumeni Syndrome: a mechanism of cancer predisposition?PMID 9018113Read ↗

Radiation-induced G1 arrest is not defective in fibroblasts from Li-Fraumeni families without TP53 mutations.Semantic proximity Read ↗

Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.Semantic proximity Read ↗

Unaffected Li-Fraumeni Syndrome Carrier Parent Demonstrates Allele-Specific mRNA Stabilization of Wild-Type TP53 Compared to Affected Offspring.Semantic proximity Read ↗

Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations.Semantic proximity Read ↗

Delayed chromosome changes in gamma-irradiated normal and Li-Fraumeni fibroblasts.Semantic proximity Read ↗

Allele-specific wild-type TP53 expression in the unaffected carrier parent of children with Li-Fraumeni syndrome.Semantic proximity Read ↗

Aberrant p21WAF1-dependent growth arrest as the possible mechanism of abnormal resistance to ultraviolet light cytotoxicity in Li-Fraumeni syndrome fibroblast strains heterozygous for TP53 mutations.Semantic proximity Read ↗

Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.Semantic proximity Read ↗

Single‐cell analysis of p16INK4a and p21WAF1 expression suggests distinct mechanisms of senescence in normal human and Li‐Fraumeni Syndrome fibroblastsSemantic proximity Read ↗

DNA damage-associated dysregulation of the cell cycle and apoptosis control in cells with germ-line p53 mutation.Semantic proximity Read ↗

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.Semantic proximity Read ↗

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.Semantic proximity Read ↗

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